Thompson Rivers University
Thompson Rivers University

Environmental Sciences Seminar Series: Agricultural fungicides and clinical drug resistance in the human pathogen Aspergillus fumigatus

Dr. Jianping Xu,
Ph.D., Department of Biology, McMaster University, Ontario

Abstract

Drug-resistance has become a global health threat. While most of our attention has been focused on bacterial pathogens, drug resistance in eukaryotic pathogens, including fungal pathogens, have also become increasingly common.

Many of the human fungal pathogens have an environmental reservoir and are widely distributed in a diversity of ecological niches, including agricultural fields.

Due to the structural and functional similarities between agricultural fungicides and many of our antifungal drugs used in clinics, there have been growing concerns about the threat that agricultural fungicide use will lead to clinical drug resistance in human fungal pathogens.

In this presentation, I will share our recent results on this issue in the opportunistic human fungal pathogen Aspergillus fumigatus, at both the local and the global levels.